Kulliyāt. Éd. Manṣūr Rastegār Fasā’ī, Tehrān, Mīrāṯ-i Maktūb, 1382/2003, 459 p. [Œuvres complètes]

Théories Complètes Autour Des Arbres

Mol086462 459..475

Positive allosteric modulators (PAMs) of a7 nicotinic acetylcholine receptors can enhance ion channel currents and downstream effects of a7 stimulation. We investigated the approach of using noncompetitive antagonists to regulate a7 receptor function, potentially distinguishing effects requiring ion channel currents from signaling induced by nonconducting states. Three small readily reversible ...

Dmd061051 459..466

It is useful to identify endogenous substrates for the evaluation of drug-drug interactions via transporters. In this study, we investigated the utility of bilirubins, substrates of OATPs and MRP2, and bile acids and substrates of NTCP and BSEP, as biomarkers for the inhibition of transporters. In rats administered 20 and 80 mg/kg rifampicin, the plasma levels of bilirubin glucuronides were ele...

Jcb_200810029 459..474

The Rockefeller University Press $30.00 J. Cell Biol. Vol. 185 No. 3 459–473 www.jcb.org/cgi/doi/10.1083/jcb.200810029 JCB 459 Correspondence to Richard W. Wozniak: [email protected] Abbreviations used in this paper: CCD, charge-coupled device; kap, karyopherin; mRFP, monomeric red fluorescent protein; NE, nuclear envelope; NLS, nuclear localization signal; NPC, nuclear pore complex; nup...

Dmd054155 459..468

Well-established techniques are available to predict in vivo hepatic uptake and metabolism from in vitro data, but predictive models for biliary clearance remain elusive. Several studies have verified the expression and activity of ATP-binding cassette (ABC) efflux transporters central to biliary clearance in freshly isolated rat hepatocytes, raising the possibility of predicting biliary cleara...